Dietary Intake of Omega Fatty Acids and Brain Health

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Omega fatty acids are well known to be important for the normal functioning of our body. These fatty acids are essential for the formation of the cell membrane. They play a critical role in brain health. In addition, they are crucial for fertility, visual acuity, and optimal cardiovascular health. Omega-3 fatty acids also have an anti-inflammatory effect.

DHA is an omega-3 fatty acid. Omega fatty acids belong to a group called polyunsaturated fatty acids (PUFA). There are several kinds of omega-3 fatty acids, but for humans, three of them are considered to be essential. These are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

ALA is a short-chain fatty acid that cannot be made by our body and thus regarded as essential. EPA and DHA are classified as long-chain fatty acids. Our body can produce them in small quantities and a very inefficient manner. This is why one’s diet should provide enough of the essential and semi-essential omega-3 fatty acids. ALA is the only fatty acid which is present in plant-based food products.

Although EPA and DHA, both of which are particularly essential for brain health, can be produced in the body from ALA, the conversion process is not very efficient. It is believed that only ~15% of dietary ALA can be converted to EPA or DHA. ALA is present in canola oil, flaxseed oil, and in some other plant oils in sufficient quantities, whereas DHA and ALA are mainly present in seafood (various varieties of fish) and found in small amounts in other animal or poultry products.

Research has shown that although fish are rich in omega fatty acids, they are not able to produce DHA or EPA. In fact, they get omega-3 fatty acids by ingesting phytoplankton. Phytoplankton, in turn, get DHA and EPA by eating microalgae that are able to produce these fatty acids. These findings draw attention to two important facts: the importance of fish and animal products in our diet for optimal cognitive health and the importance of preserving the fragile environmental balance where everything is interconnected.

Omega-3 fatty acids are essential for the formation of phospholipids that are in turn required for cellular membranes. DHA is particularly critical for brain health, as demonstrated by its high content in the brain. Furthermore, since DHA helps to reduce the inflammatory responses, it may have a neuroprotective action.

There are lots of studies regarding the optimal intake of omega-3 and omega-6 fatty acids and their optimal ratio in one’s diet. However, the recommendations in this regard remain inconclusive. Rather than focusing on the total amount of omega fatty acids or the ratio of various fatty acids, one should focus on the overall dietary intake of EPA and DHA.

Although EPA and DHA have been accepted to be essential for wellbeing, healthy aging, and slowing down or preventing neurodegeneration, their levels are rarely assessed in clinical conditions. There is no standardized, universally accepted range, but the most widely accepted normal level is ~3–4% of all plasma phospholipids (for EPA and DHA combined).

Plasma or serum fatty acid values are not very accurate, as they may change according to the content of recent meals. For this reason, many researchers recommend checking the content of EPA and DHA inthe red blood cell membranes, as this can give the approximate average of the last 120 days. At present, for European and American populations, 3–5% of EPA and DHA in erythrocyte membranes is considered in the normal range. In the Japanese population for example, where consumption of seafood is much higher, these numbers may be much higher too.

So what are the dietary recommendations for Omega-3s?

At present, for a healthy brain, it is recommended to consume 1.6 g of omega-3s daily for males, and 1.1 g daily for females. As mentioned earlier, specific attention should be paid to the content of DHA and EPA in food items. Flaxseed oil, chia seeds, and walnuts are all rich in ALA. However, DHA and EPA are mainly present in fish, seafood, and poultry. Considering that only a small amount of ALA can be converted to DHA or EPA, it puts vegans at risk of developing a deficiency in these omega acids and thus raises the risk of neurodegenerative disorders.

To counter the deficit of DHA in plant-based products, many manufacturers have started to fortify soy beverages, juices, and milk products with DHA. Dietary supplements are another way of obtaining sufficient amounts of DHA. However, as most dietary supplements are based on fish oil or krill oil, if a person is strictly vegetarian, they can take algal oil-based supplements.

The National Health and Nutrition Examination Survey (NHANES) 2011-12 indicates that most of the population in the US are obtaining enough dietary omega-3 fatty acids. However, the majority of omega fatty acids are coming from a plant-based diet, meaning that American food is rich in ALA but deficient in EPA and DHA.

Diagnosing the omega-3 deficiency is not an easy task, as there is no lower cut-off value. Researchers don’t currently know at which level an omega fatty acid insufficiency may start causing problems. Things get complicated further by individual differences. Present scientific data are insufficient to know at what level there is a risk of neural deficits, visual impairment, or alterations in immune responses. However, some people may develop specific dermatological signs in the omega-3 deficiency, like scaling of the skin or unexplained dermatitis.

Classical omega-3 deficiency is rare in the US, but considering the importance of DHA and EPA for healthy aging and cognitive capacity, one may suppose that strict vegans, vegetarians, or those who don’t eat fish may be at higher risk when compared to those that do eat fish without supplementation.


Dyall, S. C. (2015). Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA, DPA and DHA. Frontiers in Aging Neuroscience, 7. doi:10.3389/fnagi.2015.00052

McNamara, R. K. (2010). DHA Deficiency and Prefrontal Cortex Neuropathology in Recurrent Affective Disorders. The Journal of Nutrition, 140(4), 864–868. doi:10.3945/jn.109.113233

Office of Dietary Supplements – Omega-3 Fatty Acids.

Weiser, M. J., Butt, C. M., & Mohajeri, M. H. (2016). Docosahexaenoic Acid and Cognition throughout the Lifespan. Nutrients, 8(2). doi:10.3390/nu8020099

Image via pixel2013/Pixabay.

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In a World of Never Ending Tension, Seek Compassionate Neutrality

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Amidst the rising tensions in the world around us, people are finding themselves in the unique position of having to make hard decisions about choosing passive observation or active participation, causing some to toss their opinions into the fray of the multitude of voices speaking out within society today.

In contrast to what we have been accustomed to living and being for several decades, the pendulum of Change has begun its swing towards the opposite direction. The social tension created from this shift in direction has many of us unsettled. Enough so that many of us have turned inward in order to make sense of our external reality.

The need to seek balance and stability is inherent within us as human beings. We are meant to understand the other person’s point of view and seek the middle ground in between our two views in order to create perspective. Out of that informed perspective, we make decisions on how to act, our behavior evolves from those decisions, and consequently, our lives come into being from those personal thoughts and actions. This is how human beings are naturally designed to grow, evolve, and become within a constantly ever-changing world. If we are in the right place (along the spectrum of choices), at the right time (to make a decision), then right action (behavior and action) is effortless as we pivot our way into a greater life. This is one of the key tenets of my book, How Me Found I: Mastering the Art of Pivoting Gracefully Through Life.

Compassionate Neutrality vs. “My Way or the Highway”

The word “Dual” means two or something composed of two parts – harmony and balance is achieved in the coming together. The word “Duality” is when the two parts are in opposition to each other – competitive adversaries moving away from each other towards extreme polarization.

In that context, we are naturally hardwired to seek balance, “true inner balance”. Yet our external world is filled with ego-driven polarization ? “duality” ? the corrupted version of what “dual” really means. Because we are naturally designed to always seek balance (whether we are aware of it or not) and because the only constant we can expect in life is “Change”, then balance in an environment of dynamic change is achieved through a “two-party system”, a dual-system structure of compensating complimentary counterparts. As humans, psychologically our dual-system structure is the Ego-Heart handshake. This uniquely human complimentary relationship is inherent within what I call a “Natural Person”. To strive for continual balance is our natural state of mind in dealing with changing realities.

Unfortunately, our society, in its current presence of mind, does not recognize that the ego and the heart has a dual-system relationship, meant to counter balance each other so that we humans can continue to evolve within an ever-changing dynamic environment. For many of us, as we age and grow, the individual personalities that we exhibit outwardly are the reflections of our egos maturing as we learn how to adhere to the conditional social norms set forth for us to survive and operate within society. In contrast to the “natural person”, this ego-developed persona is what I call our “Conditioned Personality”.

Today, the word “dual” has become synonymous with the word “duality”, “It’s my way or the highway,” or “I’m right, you’re wrong”. Absent of the true meaning of a two-party system of balance, we have disintegrated into a mindset of where everything is now seen from the corrupted filters of polarized duality. Collaborative and communal dialogue has given way to personalized monologues based on absolute judgment and opinion.

This need to convince people that one way, and only one way, “my way”, is the cause for the rising tensions in the world today, as evidenced in the political, socio-economic, and ethno-diverse arenas of discussion. Unaware that balance is inherently a desire that we are hardwired for and ignorant that it is a partner to the heart, the ego interprets that innate desire as a need to convince others that its viewpoint is the right way to go and disregards, seeks to dominate, even eliminate the natural role the heart is meant to play. For the ego, all roads must lead to Rome and it is all about me, only me. There can be no other.

We all have individual egos; each convinced that its way is the correct way to go. Our own heartfelt knowing and the innate need for natural equilibrium have been mutated into a need to strive for a dominant view, absent of room for another view to exist. We have left the middle field in the center to take up position at either end of the playing field. As it meets resistance from other egos, our ego’s need for superiority can only lead to an outcome of aggressive force, more domination, and ultimately violence. We will kill to be right. We must be right at all costs. The end justifies the means.

And yet, the heart does exist and is very much a part of our physical and psychological makeup. It cannot be ignored, subjugated, or disregarded. Without the heart, we physically cease to exist. Without the heart, we have no conscience. It is through the heart that we connect to the greater wholeness of life in accordance to God, Nature, and the Universe, whichever you choose to refer to the larger part of who we are. The heart inherently knows that balance is necessary for our very own existence as a species. It defines our humanness, guides our humanitarian endeavors, and nourishes our humanity. It knows that it is the counterpart to the ego in a dual-system structure designed to move towards compassionate neutrality, thus bringing well-being into our lives. It is what allows us to respond to the environment in a nonjudgmental and loving way. It doesn’t need to be justified; it just needs us to be aware so that it can guide the ego towards creating a better life. Together, this heart-ego handshake is what allows us to make sense of what is happening in our extrinsic environment and make the right intrinsic decisions that can mutually benefit ourselves and others, not only ourselves. It is this communal awareness that we are both individually a person, and yet connected to each other as part of an overall human community, that gives us comfort that we are truly ever alone, unprotected, isolated, or abandoned. This awareness is the umbilical existence of our personality within the nesting doll collective of the human species. If we take care and look out for the welfare of others, then in turn we also receive benefit for our own self. Vice versa, if we look for balance within, then our external society also receives the benefit of that internal balance because we will emanate that behavior out into our external world.

In order for us to de-escalate the rising tension and violence in the external world of our society today, we, as members of humanity, need to look within and seek balance the way a natural person would. We need to reestablish the dual-system structure of the ego-heart handshake through intention, voice, and action. Because we are human and inherently designed for balance, we will naturally always seek to return to a state of compassionate neutrality; regardless of how long it takes to do so and despite what our ego thinks. The pendulum will eventually swing from any extreme edge to the center fulcrum.

So when we are at the extreme edge of a pendulum swing (the ego’s viewpoint), the pull from the other extreme edge (the heart’s viewpoint) will become intense enough to cause the pendulum to begin swinging back to the center where the heart’s communal compassion and a neutral ego’s informed judgment jointly resides. It is Mother Nature’s way of ensuring survival in a dynamically changing way.

The fallacy of our egos not understanding this natural fundamental principle of life will cause us to resist that innate impulse of allowing the other viewpoint to change our mind. Instead, we will literally fight to enforce our viewpoint to maintain our position. We don’t want the pendulum to swing at all. We want to remain in status quo, defiant to the extreme, and will react violently, determined to maintain our current position, against all natural forces of movement. This is the cause of the rising tensions in our world today.

We All Have a Choice

As an alternative, may I suggest that it is compassionate neutrality that we all seek, an aligned response to the natural forces of constant change occurring within our environment. It is what Buddhism calls, “the middle way”. It is operating from the center fulcrum of the pendulum swing, the vesica piscis of creation, the ability to see both sides and optimally benefit from the combined viewpoints. It is living life from both the macro and micro views of both the mountain peak and the valley below. This is how we survive, evolve, and grow as humans being humans, citizens of humankind, and as members of the human species.

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Safety Nets: Travel After Brain Injury

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There’s so much out there that beckons—family, friends, ethnic textiles, and, more recently, the writers’ world. I am compelled to answer the call—all the calls! I reject the invalid role that my bloody brain repeatedly tries to thrust on me.

In order to live a full life, I’ve had to learn to set up safety nets wherever I go.

Before the brain injury, I had no difficulty living a fast-paced life. I combined a full-time job with a variety of extra curricular activities including time-consuming hobbies, such as weaving and dragon boating. Travel was an integral part of my life, with trips to conferences, workshops, and with family and friends at home and abroad.

Now, in the wake of my injury, I can’t do nearly as much. Tasks that in my past life were a matter of course, such as grocery shopping and driving, deplete my resources. Travel now drains me, especially when it involves flying. Contending with the high volumes of sensory input streaming in at airports and in flight wears me out.

I’ve had to learn to apply coping mechanisms and compensation techniques to function with my damaged brain. Though pacing myself to prevent debilitating fatigue would seem easy to apply, for me, it is one of the hardest adjustments I’ve had to implement. When I travel, it’s especially difficult.

When I’m outside my home territory, having less control over the agenda hampers any attempts to slow down. Also, I don’t want people to worry. I don’t want to call attention to myself. I don’t want to miss out, and I don’t want to slow others down.

Another obstacle in my way is that future events, including possible sources of trouble, now mean less to me. As far as I’m concerned, much of the future is abstract. It’s as if the wiring between cause and effect, between my notion of past and future, is faulty.

Trips often don’t seem real until I actually land at the destination. As a result, planning and preparations don’t make sense. I usually pack for an upcoming trip at the last moment, and when I finally get to it, I have to force myself to do it. In my mind, there’s no good reason for me to undertake a task that now feels so overwhelming in its complexity. Since the injury, poor organizational skills and the difficulties in managing high volumes of data—figuring out what I need to pack, how to arrange it in my luggage, what bags should I take—are daunting.

In time, as I healed, I became better able to manage my bloody brain. I learned to set myself a list of unbreakable rules that help me prepare for trips. A side effect of my brain injury, a strong OCD (obsessive-compulsive disorder) streak, has a surprising benefit: I have a list of basics I need to pack that I follow religiously, plus a set way to organize items in my suitcase.

My rules also include arranging for safety nets.

I knew the trip to visit my family in Israel would be grueling. I knew better than to trust my own judgment. If I hoped to convince my bloody brain to cooperate, I needed someone to watch out for me, to keep me out of trouble.

Before the trip to Israel, I spoke to my sister about my anxiety. She understood and empathized—she’s walked in my shoes. She too has cavernous angiomas that have bled. Like me, she is often tempted to outpace herself. But unlike me she is assertive, and when all hell breaks loose with her bloody brain, she knows to take it easy and to rest despite outside pressure. I, on the other hand, have trouble protecting myself, no matter how bad shape I’m in.

During the trip, she shielded me from ambitious plans from well-meaning family and friends who wanted me to participate in activities that would drain my resources. And she also shielded me from myself; I was excited to spend time with my family, not wanting to cause concern, reluctant to disappoint, and too willing to go along with the crowd.

Unfortunately, the safety nets don’t always work. Some of the changes that the bloody brain brought about get in the way. I am more emotionally volatile now, and often, my emotions drive me instead of reason. In addition, my impaired memory and poor grasp of the connection between cause and effect often results in me downplaying potential difficulties.

During my first couple of days in Israel, I didn’t listen to my sister’s advice. I was sure I knew better and that I would be fine. Even after the bloody brain lashed out at me with a crippling headache, I felt that she was being overprotective. I did finally listen to her—not because I fully agreed with her, but because I didn’t want to upset her.

As my brain rewired post-injury, my memory and my ability to make connections improved. As my self-awareness grew and I became more in-tune with myself and the bloody brain, planning ahead was easier.

But even now, more than a decade since the surgeries, when I realize that common sense says, “wait a bit, take a break, don’t do so much,” there is still a niggling little voice inside me telling me that it’s not really necessary. I still overstretch myself, though nowhere near as much as I used to. I’m doing better now, I’ll be fine.

Now, where did I put that safety net?

Image via ijmaki/Pixabay.

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Social Media Anxiety Disorders: What’s Going on in the Brain?

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Too much of anything can be dangerous, and social media is no exception. Today many of us spend more time on internet-enabled devices than even sleeping. Due to this overindulgence in social media and the internet, we may become socially reclusive rather than inclusive. This, in turn, may lead to various physical and mental health problems.

Nowadays, around two billion residents of our planet are online. Hundreds of millions of emails and social messages are exchanged each day. Perhaps, this online over-engagement is becoming more of a problem. The amount of time we spend online and on social media is increasing each year. It is estimated that most people spend more than two hours each day on social media in the US.

Although social media anxiety and addiction are still not recognized as individual disorders, most investigations support the view that mental issues related to internet overuse are on the rise. Moreover, it seems to be a particularly big problem in younger people. Most individuals nowadays have their first exposure to the internet while in school. Overuse of the internet may lead to problems with concentration, sleep deprivation, failure to exercise, anxiety, and even depression. Although studying the prevalence of internet addiction or social media addiction is challenging, it could be affecting as many as 10% of people in certain sections of society.

Is social media engagement a disorder?

Is social media engagement itself a disorder? Perhaps the answer is both yes and no. It is no secret that some people get too submerged in the internet and social media. They feel bad if they do not get likes or see negative comments on their posts, and may even get depressed. Many others, however, think that social media is helpful in overcoming loneliness and depression, having a positive effect on self-esteem. The supporters of social media are saying that the compulsion to go online is not associated with the kind of harm done by substance abuse.

Most scientific review studies have provided mixed results, with only one thing certain: not all users gets depressed or feel anxiety with social media, but some do. For mental disorders related to internet abuse, as with any other psychological issues, there have to be predisposing factors like genetics, personality, lifestyle, other diseases, or a recent history of trauma.

Risk factors and identification of social media disorder

With all of the contradicting findings, there is still no doubt that social media disorder exists, and some people are at higher risk of developing it than others. Some individuals are more prone to get dependent on the internet, cultivate impulsive behavior, and are inclined towards risky internet use, as well as being more susceptible to social and emotional impairment, and even physical harm.

In recent years, some tools and measures have been developed to qualify and quantify the disorders related to social media and internet overuse. One of the scales that can be used to measure social media disorder assesses several items over the period of one year—preoccupation, tolerance, withdrawal, persistence, displacement (neglecting other hobbies), problems (arguments on social media), deception, escape, and conflict.

Social media addiction and neural changes

Some anatomical brain structures are well known to be associated with mood, emotion, and learning. Hence in one investigation, specific attention was given to the structures involved in the limbic system and reward pathway.

In the study, 20 subjects known to be addicted to social media were examined for any morphological changes in the brain, with the help of MRI. The study identified changes characteristic of impulsive behavior, with a bilateral decrease in grey matter in the amygdala without any changes in the nucleus accumbens. In contrast to other types of addiction, the anterior and mid-cingulate cortex was not found to be impaired in social media addiction, indicating that the inhibitor function of these structures is well-preserved in this condition. The study demonstrated both similarities and differences between the structural changes in the brain in social media addiction and in addiction related to substance abuse or gambling.

Other health aspects

Social media is a powerful tool that affects multiple facets of life. It has an additive effect on our already increasing sedentary lifestyle. Hence it is not stretch of the imagination that is is related to increased risk of obesity, insulin resistance, cardiovascular ailments, and other non-communicable diseases.

People who use social media too often are also more prone to bullying. They may get involved in risky behavior more frequently. In some people, social media addiction may also lead to disturbed sleep patterns. Moreover, adolescents are considered to be at higher risk of developing an addiction to social media.

Management of social media or internet addiction

Treatment of social media addiction-related pathologies depends on the nature of the problem. Although there is a lack of trials and evidence for treatment of social media-related mental issues, treatment is often a combination of pharmacological drugs and cognitive-behavioral therapy (CBT)—the kind of treatment that has already shown efficacy in other types of addictions, anxiety, and depression.

Although at present there are very few clinical studies on the topic, one can surmise that social media-related addiction, anxiety, depression, and other mental issues are going to become more common. It would be unwise to think that of social media disorder as merely a habit, we should keep in mind the related structural changes in the brain, imparting serious problems for an affected person.


ACOG (2016, February). Concerns Regarding Social Media and Health Issues in Adolescents and Young Adults – ACOG.  Access here.

Cash, H., Rae, C. D., Steel, A. H., & Winkler, A. (2012). Internet Addiction: A Brief Summary of Research and Practice. Current Psychiatry Reviews, 8(4), 292–298.

He, Q., Turel, O., & Bechara, A. (2017). Brain anatomy alterations associated with Social Networking Site (SNS) addiction. Scientific Reports, 7, 45064.

Li, W., O’Brien, J. E., Snyder, S. M., & Howard, M. O. (2015). Characteristics of Internet Addiction/Pathological Internet Use in U.S. University Students: A Qualitative-Method Investigation. PLoS ONE, 10(2).

Moreno, M. A., Jelenchick, L. A., & Christakis, D. A. (2013). Problematic internet use among older adolescents: A conceptual framework. Computers in Human Behavior, 29(4), 1879–1887.

Seabrook, E. M., Kern, M. L., & Rickard, N. S. (2016). Social Networking Sites, Depression, and Anxiety: A Systematic Review. JMIR Mental Health, 3(4).

Spada, M. M. (2014). An overview of problematic Internet use. Addictive Behaviors, 39(1), 3–6.

Statista (2017). Global time spent on social media daily 2017. Access here.

van den Eijnden, R. J. J. M., Lemmens, J. S., & Valkenburg, P. M. (2016). The Social Media Disorder Scale. Computers in Human Behavior, 61(Supplement C), 478–487.

Image via ijmaki/Pixabay.

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The Dangers of Antidepressants

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A fortunate knock of luck is always welcomed by scientists and researchers, yet any treatment modalities should be novel by design rather than by serendipity. Antidepressants were discovered by chance in the 1950s, and it seems that they suffer from specific deficiencies when it comes to their clinical effectiveness and safety profile. It is something that very few in the medical field negate, although the degree of disagreement may vary.

Depression—a poorly understood disorder

Depression is a heterogeneous disorder that may be characterized by a group of common symptoms, but the underlying cause may vary from person to person. Despite considerable research about the structural and neurochemical changes caused in the brain of a person suffering from depression, there is no specific brain-based test for the condition. Two of the most widely accepted diagnostic systems, ICD-10 and DSM-IV, have similar but not identical criteria. This means that they have a different threshold for various depression symptoms.

Some of the universally accepted symptoms of depression are depressed mood, fatigue, loss of interest, worthlessness, recurrent thoughts of suicide, insomnia, and alternation in appetite.

The rise of antidepressants

Both the US- and European-based statistics show a sharp increase in the prescription of antidepressants since the 1990s. Although statistics also indicate that no more than 8% of the population suffers from depression, 13% are taking antidepressants. Moreover, these drugs are much more commonly used in people above 60 years of age, with almost one-fourth of them taking antidepressants and many older adults using them for more than a decade.

Such a rise in the use of antidepressants is also explained by the fact that these drugs are given not only to treat depression. They have become a kind of all-purpose drugs that are considered useful to treat various mood disorders, painful conditions, inflammatory bowel syndrome, anxiety, panic disorders, and many more.

How antidepressants work?

Antidepressants are drugs belonging to various groups. Almost all of them work by changing the level of monoamine neurotransmitters in the brain. There are some additional effects too, as not all drugs capable of altering monoaminergic functioning may work as antidepressants.

Antidepressants change the presynaptic and postsynaptic concentration of dopamine, serotonin, and norepinephrine in the neurons, with most modern antidepressants targeting serotonin and to some extent norepinephrine. Dopamine, serotonin, and norepinephrine are vital neurotransmitters, playing an essential role in the limbic system and reward system. The drugs help to reset these systems, consequently contributing to the regain of mood and emotional balance.

Antidepressants have been shown to increase the activation of the prefrontal cortex but decrease the activation of the hippocampus, parahippocampal region, amygdala, ventral anterior cingulate cortex, and orbitofrontal cortex. These areas of the brain play an important role in shaping mood and emotions and are part of limbic and reward systems.

Apart from modifying the transmission of monoaminergic neuromediators, antidepressant drugs also have a complex effect on various receptors and the hypothalamic–pituitary–adrenal (HPA) axis. The impact of some of the novel antidepressants on different serotonin receptors (e.g., 5-hydroxytryptamine receptors) has been well-studied.

Some of the most commonly used antidepressants these days are tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and selective serotonin noradrenaline reuptake inhibitors (SSNRIs).

What are the safety issues?

When we talk about drug safety, it is not just about the adverse effect but also about the clinical efficacy. Too many side effects and little clinical effectiveness as compared to placebo could put the utility of any drug therapy under doubt.

When it comes to side effects, anticholinergic side effects like dryness of mouth, blurring of vision, and dizziness are common with most antidepressants. Most of them may also alter appetite and sexual function, and cause an upset stomach, joint and muscular pains, problems with drug interactions, irritability, mood changes, movement disorders and the risk of falling in the elderly, and much more. Moreover, these side effects continue to persist when the drugs are used long term.

The development of tolerance and withdrawal symptoms are widespread. Discontinuation syndrome can be really bad in many cases.

Perhaps the most worrisome of all the adverse effects is the higher occurrence of suicide and violence in those on antidepressants. Although there are many studies with contradicting conclusions, the majority seem to show that suicide and violence are much higher in those taking antidepressants. Moreover, abnormal behavior is equally common with the newer SSRIs and SSNRIs.

There is an abundance of literature mentioning the risk of suicide in depression. However, the efficacy of antidepressants in the prevention of depression-related suicide remains inconclusive.

Clinical studies have demonstrated that the newer non-tricyclic antidepressants are not any better in their safety profile in the elderly population.

Finally, a considerable number of studies seems to put doubt on the effectiveness of antidepressants. Some medical specialists believe that antidepressants do not help at all, and many studies support their view. Thus in one of the studies published in the JAMA, it was concluded that the therapeutic benefit with antidepressants may actually be non-existent or minimal for mild to moderate depression, with more substantial benefits in severe cases of depression.


Although the diversity of depression is well-recognized, almost all the drugs made to treat depression inhibit reuptake of one or another monoamine neuromediator, and very little has changed in our approach towards treatment since the advent of the first antidepressant drug. In order to overcome the dangers and limitations of therapy with antidepressants, there is an urgent need to create antidepressants that have a novel mechanism of action and better tolerance.  More caution should be exercised by medical professionals when prescribing anti-depressants, as the ability to promote positive effects in many patients is questionable.


Bet, P. M., Hugtenburg, J. G., Penninx, B. W. J. H., & Hoogendijk, W. J. G. (2013). Side effects of antidepressants during long-term use in a naturalistic setting. European Neuropsychopharmacology, 23(11), 1443–1451.

Bielefeldt, A. Ø., Danborg, P. B., & Gøtzsche, P. C. (2016). Precursors to suicidality and violence on antidepressants: systematic review of trials in adult healthy volunteers. Journal of the Royal Society of Medicine, 109(10), 381–392.

Delaveau, P., Jabourian, M., Lemogne, C., Guionnet, S., Bergouignan, L., & Fossati, P. (2011). Brain effects of antidepressants in major depression: A meta-analysis of emotional processing studies. Journal of Affective Disorders, 130(1), 66–74.

Fournier, J. C., DeRubeis, R. J., Hollon, S. D., Dimidjian, S., Amsterdam, J. D., Shelton, R. C., & Fawcett, J. (2010). Antidepressant Drug Effects and Depression Severity: A Patient-Level Meta-analysis. JAMA, 303(1), 47.

Hollinghurst, S., Kessler, D., Peters, T. J., & Gunnell, D. (2005). Opportunity cost of antidepressant prescribing in England: analysis of routine data. BMJ, 330(7498), 999–1000.

Köhler, S., Cierpinsky, K., Kronenberg, G., & Adli, M. (2016). The serotonergic system in the neurobiology of depression: Relevance for novel antidepressants. Journal of Psychopharmacology, 30(1), 13–22.

Mahar, I., Bambico, F. R., Mechawar, N., & Nobrega, J. N. (2014). Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects. Neuroscience & Biobehavioral Reviews, 38(Supplement C), 173–192.

National Collaborating Centre for Mental Health (UK). (2010). THE CLASSIFICATION OF DEPRESSION AND DEPRESSION RATING SCALES/QUESTIONNAIRES. British Psychological Society. Retrieved from

Pratt, L. A., Brody, D. J., & Gu, Q. (2017). Antidepressant Use Among Persons Aged 12 and Over: United States, 2011–2014.

Image via HASTYWORDS/Pixabay.

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The Neurological Basis of Anxiety

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A person suffering from an anxiety disorder experiences neurology-based changes in mood and bodily functions that are discussed in more detail in this article.

As with anxiety, various personality traits and emotional responses are by-products of the interaction between our genetic coding and environmental influences. Our genes make us more receptive to some specific stimuli and play a role in developing the resilience to some other stimuli. Our brain is a plastic organ. Thus, the role of environmental factors in its development and casting cannot be negated.

Fear and stress are normal defensive reactions to threats that help our body to deal with challenges more efficiently. Anxiety is different from fear in that it is a set of emotional and somatic reactions to a future threat that may or may not be realistic. To some extent, having anxiety is a normal human reaction. However,  if it continues for a prolonged period, it may have an adverse effect on our daily life and health.

In the state of anxiety, worrying about the future makes it difficult to concentrate and leads to irritability. Somatic symptoms like palpation, sweating, and gastrointestinal changes are also common in this state. Anxiety is considered as a disorder if such symptoms persist over a period of six or more months.

Anxiety disorders are most prevalent among people with psychiatric disorders, affecting around 10% of the population at any given time. Nonetheless, only a small number of those suffering from anxiety disorders seek treatment. This can be partially explained by the difficulties in identifying the condition. General anxiety disorder, panic disorder, specific phobias, and social anxiety are some of the most common types of anxiety disorders.

What makes a person vulnerable to anxiety disorders?

The hereditary nature of various forms of anxiety disorders has been established through clinical and observational studies. Multiple studies have demonstrated that a person is at 3–5 times greater risk of developing anxiety disorders if such a condition is found among first-degree relatives. The importance of familial clustering in anxiety has been demonstrated by a number of twin studies. Other internal factors like certain personality traits also make a person more vulnerable to developing anxiety disorders.

Apart from internal factors, environmental factors may also make some people more anxious. These factors include exposure to stressful condition, drug or alcohol use, parenting style, and stressful life events.

Neuroanatomy of stress and anxiety

Higher cognitive centers in our brain are located in the prefrontal cortex. They are involved in thinking, planning, and social behavior. From an evolutionary perspective, the prefrontal cortex is the “newer” part of the brain that helps us to keep our emotional responses in check.

Most of the emotion processing takes place in more ancient parts of the cortex. These anatomical brain structures are collectively called the “limbic system”. One fundamental structure in the limbic system is the hippocampus that plays a vital role in the stress response and regulation of the hypothalamic–pituitary–adrenal (HPA) axis. Both hippocampal growth and neurogenesis play an essential role in the development of resiliency towards stress and anxiety.

But perhaps the most crucial part of the limbic system that plays a central role in the regulation of emotions is the amygdala. The amygdala is central to the formation of fear and anxiety-related memory and has been shown to be hyperactive in anxiety disorders. It is well connected with other brain structures like the hippocampus, thalamus, and hypothalamus.

Apart from anatomical changes, it is essential to understand that brain functionality or communication between various brain centers and networks takes place through neurotransmitters. In the case of emotional responses, gamma-aminobutyric acid (GABA) is known to have an inhibitory effect on emotions, while glutamate has an excitatory effect. The roles of serotonin, dopamine, and norepinephrine are also well documented in the pathogenesis of various emotional states. Other neurotransmitters that may play a role in the pathogenesis of anxiety disorders are cholecystokinin (CCK), galanin (Gal), neuropeptide Y (NPY), oxytocin (OT), vasopressin (AVP), and corticotrophin-releasing factor.

Neuroanatomical changes in stress

Most anxiety disorder cases develop in childhood, where the long-term and repetitive experience of anxiety leads to changes in specific brain structures that can be observed using neuroimaging. fMRI studies on generalized anxiety disorder (GAD) have shown a higher level of activity in the ventrolateral prefrontal cortex. Furthermore, a significant level of activity is seen in the amygdala, especially when a person is told to focus on his or her stress, as well changes in the cingular cortex and insular cortex.

During adolescence, there is an acceleration in the physical growth, along with changes in behavior, cognition, and emotional control. The development of the body during this period may result in permanent changes in various brain areas that can be implicated in the development of psychiatric disorders in adult life.

During adolescence, it might be easier to remodel various brain structures with the help of cognitive behavioral therapy or other modalities than in adults. Meanwhile, in adults, various therapeutic agents can be used to alter the biochemical structure of the brain.

For patients with anxiety disorders, selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are often prescribed as the first line treatment. Other drugs that can be used to treat various anxiety disorders include monoamine oxidase inhibitors, tricyclic antidepressants, and benzodiazepines.

Despite the immense progress in our understanding of neuroanatomy and neuroendocrinology, not all cases of anxiety can currently be treated. However, the latest research on the subject has improved the selection of drugs available for various anxiety disorders. For instance, benzodiazepines are known to be more efficient in the treatment of panic disorders than GAD.

As neuroimaging technologies continue to evolve, a better understanding of the neurobiology of anxiety is bound to influence the way we treat anxiety and other related disorders.


Andrews, G., Stewart, G., Allen, R., & Henderson, A. S. (1990). The genetics of six neurotic disorders: a twin study. Journal of Affective Disorders, 19(1), 23–29. doi:10.1016/0165-0327(90)90005-S

Bandelow, B., & Michaelis, S. (2015). Epidemiology of anxiety disorders in the 21st century. Dialogues in Clinical Neuroscience, 17(3), 327–335. PMCID: PMC4610617

Bystritsky, A., Khalsa, S. S., Cameron, M. E., & Schiffman, J. (2013). Current diagnosis and treatment of anxiety disorders. Pharmacy and Therapeutics, 38(1), 30–57. PMCID: PMC3628173

Martin, E. I., Ressler, K. J., Binder, E., & Nemeroff, C. B. (2009). The neurobiology of anxiety disorders: brain imaging, genetics, and psychoneuroendocrinology. The Psychiatric Clinics of North America, 32(3), 549–575. doi:10.1016/j.psc.2009.05.004

Miguel-Hidalgo, J. J. (2013). Brain structural and functional changes in adolescents with psychiatric disorders. International Journal of Adolescent Medicine and Health, 25(3), 245–256. doi:10.1515/ijamh-2013-0058

Morris-Rosendahl, D. J. (2002). Are there anxious genes? Dialogues in Clinical Neuroscience, 4(3), 251–260. PMCID: PMC3181683

Ravindran, L. N., & Stein, M. B. (2010). The pharmacologic treatment of anxiety disorders: a review of progress. The Journal of Clinical Psychiatry, 71(7), 839–854. doi:10.4088/JCP.10r06218blu

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Do Today’s Technological Advances Threaten Our Species?

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A lot of public back-and-forth banter has been going on lately between two giant tech personalities: Elon Musk and Mark Zuckerberg. Their public debate centers on whether or not artificial intelligence (AI) represents an existential threat to humanity.

For example, Elon Musk, when speaking at the National Governors Association in July said:

AI is a fundamental existential risk for human civilization, and I don’t think people fully appreciate that…It’s the greatest risk we face as a civilization [that will cause World War III]

Mark Zuckerberg on the other hand, touts the benefits of AI and says that Elon Musk’s doomsday predictions about AI are “pretty irresponsible.”

This prompted Elon Musk to fire back that Mark Zuckerberg’s understanding of AI is “pretty limited.”

So who is right? Only time will tell of course, but by my science-based speculation, I would say the evidence favors Musk. And greater brains than my own are telling us that artificial intelligence could be the end of Homo sapiens or any other Homo that follows, including Bill Joy, Stephen Hawking, Vernor Vinge, Shane Legg, Stuart Russell, Max Tegmark, Nick Bostrom, James Barrat, Michael Anissimov, and Irving Good. Brilliant minds, Nobel Prize winners, renowned inventors, and IT pioneers are all on record giving us warnings.

Of course other existential threats to Homo sapiens are possible and could come in the form of another bolide impact like the one that doomed the dinosaurs 66 million years ago or a supervolcano leading to extreme global weather events, a phenomena that also affected early species. Unlike the relentless human pursuit of technologies that could alter, if not eliminate, our species, these threats are essentially out of our control.

Genetic engineering, especially if aided by AI, could lead to the future speciation of Homo sapiens and pose yet another existential threat. Lee Silvers, in his book Remaking Eden, envisions a future society practicing an extreme form of behavioral isolation based on genetic engineering. In this society, only a small portion of the population, which he calls the GenRich, have the financial means to genetically enhance their children.

Over decades, the GenRich use genetic engineering techniques to optimize a variety of human traits—such as intelligence, athletic skill, physical appearance, and creativity—that give them a controlling position in society. Over time, cultural disparity between this GenRich minority population and the remaining “naturals” becomes so great that there’s little interbreeding between the two groups. Such a scenario could lead to the genetic development of a postzygotic reproductive barrier.

In other words, genetic engineering could eventually lead to a new species of humans. Once this occurs, the long-term results are unpredictable. This new species—I call it Homo nouveau—like the GenRich, may not be an existential threat, at least in the early centuries or millennia.

It’s uncertain what could happen when two human species try to coexist. We know things didn’t work out very well for the Neanderthals after Homo sapiens arrived. In fact, the same is true for Homo heidelbergensisHomo erectus, Homo denisova, and every other Homo species that may have coexisted with Homo sapiens.

In considering all the possible existential threats to us humans, genetic engineering is a possibility in the not too distant future—say in the next two to four centuries. However, if Elon Musk is right AI could supersede that in one or two centuries if we’re unsuccessful in controlling it. Then again, at any time we could be hit by a bolide. None of this bodes well for us.


L. Grossman, “2045: The Year Man Becomes Immortal”, Time Magazine, February 10, 2011. Access here.

Hawking, S., Tegmark, T., Russell, S. (2017). Transcending Complacency on Superintelligent Machines. Huffington Post. Access here.

Bostrom, N. Superintelligence: Paths, Danger, Strategies, Oxford: Oxford University Press, 2014.

F. Heylighen, “Return to Eden? Promises and Perils on the Road to Global Superintelligence,” in The End of the Beginning: Life, Society and Economy on the Brink of the Singularity, Ben and Ted Goerzel, eds., Humanity + Press, 2015.

Image via frolicsomepl/Pixabay.

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